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KMID : 1039420200540050426
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Journal of Pathology and Translational Medicine
2020 Volume.54 No. 5 p.426 ~ p.431
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Renal intravascular large B cell lymphoma: the first case report in Korea and a review of the literature
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Kim Moon-Sik
Chung Hae-Rim
Yang Woo-Ick
Jeong Hyeon-Joo
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Abstract
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Herein, we describe the first case of renal intravascular large B cell lymphoma in Korea occurring in a 66-year-old female. She presented with mild fever and dyspnea. On physical and laboratory evaluations, hemophagocytic lymphohistiocytosis was suspected, but the bone marrow biopsy results were unremarkable. During the work-up, massive proteinuria developed, which led to a renal biopsy. The renal architecture was relatively well-preserved, but the glomeruli were hypercellular with the infiltration of atypical, large lymphoid cells with increased nucleus-cytoplasm ratio and clumped chromatin. Similar cells were also present in the peritubular capillaries. The tumor cells exhibited membranous staining for CD20 and CD79a. After the diagnosis of intravascular large B cell lymphoma, the patient received rituximab-based chemotherapy under close follow-up.
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KEYWORD
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Intravascular large B cell lymphoma, Kidney glomerulus, Peritubular capillary
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